Jon Lester
| Date | Team | Opponent | Result | IP | H | R | ER | BB | SO | PA | 2B | 3B | HR | GO | FO | MISC |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2021-04-30 | WAS | vs. MIA | W, 2-1 | 5.0 | 5 | 0 | 0 | 2 | 1 | 21 | 2 | 0 | 0 | 8 | 5 | SP |
| 2021-05-06 | WAS | vs. ATL | L, 3-2 | 5.0 | 4 | 3 | 3 | 2 | 5 | 20 | 1 | 0 | 0 | 3 | 6 | SP, L |
| 2021-05-12 | WAS | vs. PHI | L, 5-2 | 6.0 | 6 | 1 | 1 | 3 | 4 | 25 | 1 | 0 | 0 | 4 | 7 | SP |
| 2021-05-17 | WAS | @ CHC | L, 7-3 | 5.1 | 8 | 5 | 5 | 0 | 4 | 22 | 1 | 0 | 3 | 5 | 5 | SP, L |
| 2021-05-22 | WAS | vs. BAL | W, 12-9 | 4.0 | 5 | 6 | 6 | 3 | 4 | 19 | 2 | 0 | 1 | 3 | 4 | SP |
| 2021-05-29 | WAS | vs. MIL | L, 6-2 | 4.0 | 5 | 1 | 1 | 0 | 4 | 17 | 1 | 0 | 0 | 2 | 5 | SP |
| 2021-06-02 | WAS | @ ATL | W, 5-3 | 5.2 | 5 | 1 | 1 | 2 | 3 | 24 | 0 | 0 | 1 | 9 | 4 | SP |
| 2021-06-08 | WAS | @ TBR | L, 3-1 | 3.2 | 4 | 1 | 1 | 4 | 2 | 19 | 0 | 0 | 1 | 3 | 5 | SP |
| 2021-06-14 | WAS | vs. PIT | W, 3-2 | 5.1 | 6 | 2 | 2 | 1 | 2 | 23 | 2 | 0 | 1 | 11 | 3 | SP |
| 2021-06-19 | WAS | vs. NYM | W, 6-2 | 6.0 | 7 | 2 | 2 | 0 | 6 | 25 | 2 | 0 | 1 | 6 | 6 | SP, W |
| 2021-06-25 | WAS | @ MIA | L, 11-2 | 2.1 | 5 | 7 | 7 | 3 | 1 | 16 | 2 | 0 | 1 | 5 | 1 | SP, L |
| 2021-06-30 | WAS | vs. TBR | W, 15-6 | 5.0 | 7 | 5 | 5 | 2 | 3 | 24 | 1 | 0 | 2 | 4 | 8 | SP, W |
| 2021-07-05 | WAS | @ SDP | W, 7-5 | 3.1 | 6 | 5 | 2 | 4 | 2 | 21 | 2 | 0 | 1 | 4 | 2 | SP |
| 2021-07-10 | WAS | @ SFG | L, 10-4 | 2.2 | 9 | 8 | 3 | 2 | 1 | 21 | 1 | 0 | 0 | 2 | 4 | SP, L |
| 2021-07-19 | WAS | vs. MIA | W, 18-1 | 7.0 | 6 | 0 | 0 | 0 | 7 | 26 | 2 | 0 | 0 | 7 | 6 | SP, W |
| 2021-07-24 | WAS | @ BAL | L, 5-3 | 5.0 | 3 | 3 | 3 | 1 | 2 | 19 | 1 | 0 | 2 | 5 | 8 | SP, L |
| 2021-08-03 | STL | vs. ATL | L, 6-1 | 5.0 | 9 | 6 | 6 | 2 | 4 | 24 | 0 | 0 | 2 | 7 | 2 | SP, L |
| 2021-08-08 | STL | vs. KCR | L, 6-5 | 5.1 | 6 | 5 | 5 | 2 | 2 | 25 | 1 | 0 | 0 | 7 | 6 | SP |
| 2021-08-14 | STL | @ KCR | W, 9-4 | 5.2 | 7 | 1 | 1 | 2 | 2 | 24 | 0 | 0 | 0 | 11 | 2 | SP, W |
| 2021-08-19 | STL | vs. MIL | W, 8-4 | 4.1 | 6 | 4 | 4 | 3 | 0 | 23 | 3 | 0 | 0 | 6 | 7 | SP |
| 2021-08-25 | STL | vs. DET | W, 3-2 | 5.0 | 7 | 1 | 1 | 2 | 4 | 21 | 3 | 0 | 0 | 5 | 3 | SP |
| 2021-08-30 | STL | @ CIN | W, 3-1 | 6.1 | 1 | 1 | 1 | 2 | 5 | 22 | 0 | 0 | 1 | 5 | 9 | SP, W |
| 2021-09-05 | STL | @ MIL | L, 6-5 | 5.1 | 6 | 1 | 1 | 2 | 2 | 23 | 1 | 0 | 1 | 9 | 4 | SP |
| 2021-09-10 | STL | vs. CIN | L, 4-2 | 7.0 | 3 | 2 | 2 | 4 | 2 | 27 | 0 | 0 | 2 | 10 | 7 | SP |
| 2021-09-15 | STL | @ NYM | W, 11-4 | 6.0 | 6 | 3 | 2 | 0 | 7 | 25 | 1 | 0 | 2 | 3 | 7 | SP, W |
| 2021-09-20 | STL | @ MIL | W, 5-2 | 6.0 | 3 | 2 | 2 | 0 | 2 | 21 | 0 | 0 | 2 | 4 | 12 | SP, W |
| 2021-09-25 | STL | @ CHC | W, 8-5 | 5.0 | 8 | 4 | 3 | 3 | 6 | 26 | 2 | 0 | 0 | 5 | 2 | SP |
| 2021-10-02 | STL | vs. CHC | L, 6-5 | 5.0 | 6 | 4 | 4 | 4 | 4 | 24 | 1 | 0 | 1 | 7 | 3 | SP |
| Total Games: 28 | ||||||||||||||||