John Wayne Middleton (April 11, 1900 – November 3, 1986) was an American Major League Baseball pitcher who played for one season. He pitched for the Cleveland Indians for two games during the 1922 Cleveland Indians season. Middleton was one of a group of players that Indians player-manager Tris Speaker sent in partway through the game on September 21, 1922 done as an opportunity for fans to see various minor league prospects.
John Middleton
| Given name: | John Wayne Middleton |
| Nicknames: | None |
| Primary Pos: | Pitcher |
| Hght/Wght: | 6'1" / 185 lbs |
| Bats/Throws: | L / L |
| Born: | Apr 11, 1900 in Mount Calm, TX |
| Died: | Nov 3, 1986 in Amarillo, TX (86 years old) |
| Debut: | Sep 6, 1922 |