Clarence Joseph "Jay" Difani (December 21, 1922 – December 3, 2003) was an American professional baseball player. He was a second baseman over parts of two seasons (1948–49) with the Washington Senators. For his career, he compiled a .333 batting average with one hit in three at-bats.
An alumnus of the University of Missouri, he was born in and, later, died in Crystal City, Missouri at the age of 80.