George Richard Piktuzis (January 3, 1932 – November 28, 1993) was an American professional baseball player, a left-handed pitcher who appeared as a relief pitcher in two games for the 1956 Chicago Cubs of Major League Baseball. The native of Chicago batted right-handed, stood 6 feet 2 inches (1.88 m) tall and weighed 200 pounds (91 kg).
Piktuzis' professional career lasted six seasons (1950–52; 1955–57). His MLB appearances came in April 1956 against the St. Louis Cardinals and Cincinnati Redlegs. He surrendered four earned runs and six hits, including a home run by Cincinnati's George Crowe, in five innings pitched. As a minor leaguer, he compiled a 34–62 (.354) record in 176 games.
George Piktuzis died in Long Beach, California, at the age of 61.