Frank Ernst Gregory (July 25, 1888 – November 5, 1955) was a professional baseball player. He was a right-handed pitcher for one season (1912) with the Cincinnati Reds. For his career, he compiled a 2–0 record, with a 4.60 earned run average, and four strikeouts in 15+2⁄3 innings pitched.
He was born in Spring Valley (town), Wisconsin and died in Beloit, Wisconsin at the age of 67.